Unsupervised hierarchical clustering. The figure shows the unsupervised hierarchical clustering of the DNA methylation data for 80 primary high-grade STS samples representing eight sarcoma subtypes. The two sarcoma subtypes that carry specific translocations (MLS and SS) are tightly separated into subgroups. The other sarcoma subtypes were dispersed into a third or fourth subgroup. DDLS, dedifferentiated liposarcoma; LMS, leiomyosarcoma; MFS, myxofibrosarcoma; MLS, myxoid liposarcoma; MPNST, malignant peripheral nerve sheath tumor; PLS, pleomorphic liposarcoma; SS, synovial sarcoma; UPS, undifferentiated pleomorphic sarcoma.