Table 1 Osteosarcoma associated loci identified by independent GWAS in three dog breeds with high rates of the disease

Greyhound

BICF2P133066

11

44405676

6.4E-07

A

1.26

0.84

0.65

44392734-44414985

22

None

BICF2P1421479

8

35448126

3.4E-05

C

1.36

0.12

0.03

35433142-35454649

22

OTX2 (50 kb)

BICF2S23118341

13

14588716

1.1E-04

T

1.20

0.34

0.19

14549973-14645634

96

None

BICF2S23325120

25

21912859

1.3E-04

A

1.19

0.56

0.41

21831580-21921256

90

None

BICF2P66597

14

49193217

1.6E-04

G

1.19

0.37

0.23

48831824-49203827

372

BMPER

BICF2P1194727

5

16085937

1.8E-04

G

1.23

0.28

0.14

16071171-16152955

82

GRIK4

BICF2G63051809

19

34134931

2.8E-04

T

1.21

0.80

0.67

33963105-34145310

182

EN1, MARCO

BICF2G630813090

16

43669044

3.0E-04

C

1.16

0.64

0.48

43665149-43737129

72

MTMR7

BICF2G630418573

15

63780452

3.4E-04

A

1.26

0.91

0.81

63767963-63800415

32

None

TIGRP2P215623

16

40896559

3.5E-04

C

1.36

0.97

0.89

40883517-41081510

198

SGCZ

TIGRP2P331221

25

43485109

3.8E-04

G

1.23

0.22

0.11

43476429-43528145

52

CCL20

BICF2S23516022

1

112990983

3.8E-04

C

1.21

0.82

0.69

112977233-113081800

105

CD3EAP, ERCC1, ERCC2, FOSB, PPP1R13L

TIGRP2P45171

3

5564882

4.0E-04

T

1.20

0.79

0.68

5162058-6465753

1,304

FER, MAN2A1, PJA2

BICF2P1090686

7

64672328

4.2E-04

C

1.16

0.57

0.43

64631053-64703475

72

CHST9

Rottweiler

BICF2P1115364

1

116524913

5.0E-07

G

1.32

0.71

0.39

115582915-116790630

1,208

Many (35 genes)

BICF2P411325

2

19515571

5.8E-06

C

1.43

0.91

0.73

19212450-19542015

330

KIAA1462

BICF2P1210630

1

122048812

1.1E-05

C

1.30

0.73

0.46

122033806-122051988

18

C19orf40, CEP89, RHPN2

TIGRP2P407733

35

18338700

1.8E-05

A

1.28

0.51

0.29

18326079-18345318

19

None

BICF2P341331

9

47659782

7.6E-05

A

1.28

0.53

0.28

47647012-47668054

21

BLMH, TMIGD1

BICF2P1129874

38

11714169

9.4E-05

T

1.24

0.49

0.26

11252518-11739329

487

FAM5C

TIGRP2P286750

21

46283811

1.1E-04

C

1.37

0.84

0.70

46231985-46363479

131

NELL1

BICF2S23533459

17

14472761

1.3E-04

C

1.39

0.18

0.01

14465884-14482152

16

None

BICF2G630590368

32

25147661

2.7E-04

A

1.35

0.95

0.81

25136302-25156153

20

EMCN

BICF2P92014

36

29651125

3.0E-04

A

1.22

0.66

0.42

29637804-29663408

26

None

TIGRP2P200071

15

38987072

3.1E-04

T

1.27

0.82

0.59

37986345-39974762

1,988

Many (15 genes)

BICF2P1164085

1

29775073

3.3E-04

G

1.24

0.46

0.23

29405587-29914411

509

EYA4, TCF21

BICF2S23712115

26

32385934

3.7E-04

G

1.35

0.91

0.76

32374093-32428448

54

ARVCF, C22orf25, COMT

BICF2G63095567

25

29671618

3.9E-04

G

1.30

0.23

0.05

29658978-29767164

108

XKR6

BICF2P841536

26

3537143

4.2E-04

A

1.26

0.48

0.30

3529343-3550075

21

FBRSL1

Irish Wolfhound

BICF2S23746532

5

15264066

2.1E-05

A

1.40

0.45

0.16

14720254-15466603

746

BLID

BICF2P1466354

18

4937944

2.7E-05

C

1.36

0.56

0.21

4266743-5854451

1,588

C7orf72, COBL, DDC, FIGNL1, GRB10, IKZF1, VWC2, ZPBP

BICF2P1225386

1

17742179

3.2E-04

C

1.31

0.46

0.19

16768869-18150476

1,382

BCL2, KIAA1468, PHLPP1, PIGN, RNF152, TNFRSF11A, ZCCHC2

BICF2P1125643

9

19623231

4.3E-04

C

1.75

0.14

0.02

18896060-19633155

737

ABCA5, KCNJ16, KCNJ2, MAP2K6