Figure 5From: Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAsExpression of elncRNA but not plncRNA loci is associated with enhanced expression levels of neighboring protein-coding genes. (A) Fold difference, Δ, in expression of the neighboring loci in the stage in which the expression level of the reference locus (protein-coding gene, plncRNA or elncRNA) is maximal relative to the stage in which it is minimal. Δ is defined as (Expressionmax - Expressionmin)/Expressionmin. Two-tailed Mann–Whitney test, *P < 0.05; NS, not significant. Fold-change (FC) between Ter119+ and colony-forming unit erythroblast (CFUE) expression (measured by quantitative PCR) of (B) elncRNAs (green) or (C) plncRNAs (blue) (x-axis) and their respective protein-coding gene (PC, y-axis). Data used for the preparation of this figure are available in Additional file 16. Horizontal and vertical bars represent the standard error of the mean for fold-change of lncRNA and protein-coding genes, respectively. Dashed blue and green lines represent the elncRNAs’ and plncRNAs’ linear regression functions, respectively.Back to article page