Figure 3

Physical constraints of chromosomal architecture. (A) Number of reads per million for four distinct classes of interactomes. Viewpoint: circular chromosome conformation capture (4C) reads that map on the same chromosome arm as the viewpoint. Viewpoint (removed): interactions mapping the viewpoint’s arm, excluding interactions that map within 2 Mb distance on either side of the viewpoint. Cis: 4C reads that map to the other arm of the chromosome harboring the viewpoint. Trans: 4C reads that map to all other chromosome arms. (B) The relative distance to the centromere (0 at the centromere, 1 at the telomere) in which 50% of the 4C reads can be found depends on the relative distance of the viewpoint to the centromere. (C) The percentage of 4C reads that can be mapped to trans arms was positively correlated with the viewpoint’s absolute distance to the centromere in base pairs (bp). In all parts, red circles represents replicate A, blue represents replicate B.