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Figure 3 | Genome Biology

Figure 3

From: Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

Figure 3

In -cis miRNAs show functional effects when overexpressed. Breast cancer cell lines were transfected with miRNA mimics (20 nM) and assayed for (a) cell proliferation (Ki67), (b) phosphorylated AKT (p-AKT) levels, (c) cell viability and (d) apoptosis (cleaved PARP (cPARP)), 72 hours after transfection. The dashed lines indicate cut-off points that were considered significant (see Materials and methods). Asterisks denote significant effects. The data for cell viability are from two replicate experiments with error bars showing standard deviations.

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