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Table 2 Gene set analysis of murine classes and human subtypes

From: Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

  Human breast cancer subtype  
Mouse class Basal-like Claudin-low HER2-enriched Luminal A Luminal B Normal-like Predicted human counterpart
P-value P-value P-value P-value P-value P-value
  U C T U C T U C T U C T U C T U C T
WapINT3 Ex 0.06 0.09 0.17 - - NA - - - - 0.44 - 0.40 0.34 0.29 - - -  
Erbb2-like Ex 0.33 0.30 0.33 - - NA <1e-4* 0.01* 0.01* 0.31 - - 0.44 0.40 0.30 - - - HER2-enriched
Class3 Ex - - - 0.46 - NA 0.41 0.17 0.38 0.31 0.28 0.34 - - - 0.12 0.14 0.29  
Myc Ex 0.02* 0.01* 0.03* - - NA 0.22 0.11 0.07 - - - 0.06 0.01* 0.02* - - - Basal-like and Luminal B
PyMT Ex 0.41 0.38 - - - NA 0.28 0.09 0.08 0.08 0.33 0.46 0.02 0.10 0.12 - - -  
Neu Ex - - - - - NA 0.44 0.36 0.42 <1e-4* 0.01* 0.02 0.10 0.36 0.43 - - - Luminal A
Normal-like Ex - - - 0.14 0.21 NA - - - - 0.07 0.11 - - - <1e-4* 0.01* 5e-4* Normal-like
Class8 Ex - - - 0.09 0.06 NA 0.48 - - 0.40 0.46 0.11 - - - 0.28 0.25 0.26  
Wnt1-Late Ex 0.37 - - - - NA - - - 0.40 0.41 0.42 - 0.46 0.40 0.15 0.01* 0.21  
Wnt1-Early Ex 0.29 - - - - NA - - - 0.40 0.19 0.33 0.38 0.40 0.49 0.39 0.08 0.21  
p53null-Basal Ex 0.04 0.05 0.06 - - NA - - 0.16 - - - 0.48 0.29 0.20 - - - Basal-like
Squamous-like Ex - - 0.35 0.11 0.02* NA 0.20 - - - - - - - - 0.18 0.09 0.10  
Stat1 Ex - - - 0.37 0.32 NA 0.07 - - 0.31 0.30 0.16 - 0.48 0.41 0.38 0.39 -  
Class14 Ex - - - 0.35 0.22 NA - - - 0.17 0.14 0.01* 0.45 - 0.11 0.06 <1e-4* 0.04* Normal-like
C3Tag Ex 0.02* 0.02* 0.03* 0.38 - NA - - 0.24 - - - 0.28 0.12 0.02* - - - Basal-like
Claudin-low Ex - - 0.38 5e-4* <1e-4* NA - - - - - 0.20 - - 0.41 - - 0.17 Claudin-low
p53null-Luminal Ex 0.17 0.07 0.02* - - NA 0.35 0.23 0.15 - - - 0.24 0.24 0.16 - - -  
  1. A comparative analysis of each murine class versus each human subtype. Statistically significant observations are highlighted with an asterisk (P < 0.05, false discovery rate <0.1). Comparisons without a P-value were not found to have a positive association with each other. Abbreviation: U, UNC. C, Combined. T, TCGA. NA, not applicable.