Figure 5

Conserved signaling pathways between human-mouse counterparts. A two-class SAM (class X versus all others) was used to identify pathways highly expressed in each murine class. Pathways highly expressed with a FDR of 0% were grouped together to define a ‘pathway meta-signature’ for each murine class (with the total number of pathway signatures included shown on the left axis). The standardized, average expression values of each ‘pathway meta-signature’ were calculated in the UNC308, Combined855, and TCGA547 human datasets, which are displayed as boxplots according to their intrinsic human subtype. A subset of the pathways independently identified to be highly expressed in both human-mouse counterparts (as indicated by the asterisk) for all three human datasets is displayed below each plot.