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Figure 2 | Genome Biology

Figure 2

From: Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

Figure 2

Murine intrinsic class analysis. (A) Supervised cluster using the newly derived murine intrinsic gene list and all murine arrays in the dataset. Roman numerals next to the gray bars correspond to the enlarged regions in parts (i) to (v). (B) Dendrogram of the cluster from part (A) with the murine classes identified by SigClust highlighted. Classes with colored boxes have been determined to be human expression-based subtype counterparts. (C) Breast cancer genes and individual cell lineage marker expression profiles. (i) Claudin-low gene cluster. (ii) Luminal gene cluster. (iii) Basal gene cluster. (iv) Proliferation gene cluster. (v) Lactating gene cluster.

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