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Figure 4 | Genome Biology

Figure 4

From: Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome

Figure 4

Histone ChIP AI of individual histone modifications is generally highest at genes subject to XCI. (A) Each histone modification is shown in a separate panel (H3K4me1, H3K4me3, H3K27ac, H3K27me3 and H3K36me3). Error bars represent the standard error of the mean while the color indicates the assigned genic XCI status: genes that escape XCI and have a %Xi expression within the PAR1 range (dark green), genes that escape XCI and have a %Xi expression outside the PAR1 range (green), genes that are subject to XCI and have a %Xi expression greater than 5%Xi (red) and genes that are subject to XCI and have a %Xi expression less than 5%Xi (dark red). (B) Examples of gene body histone ChIP AI of individual gene loci from each %Xi expression level along with XIST. Significant differences between means are shown as asterisks (*P-value 0.05 to 1.0 e-5, **P-value 1.0 e-5 to 1.0 e-15, ***P-value <1.0 e-15). All P-values were corrected for multiple comparisons.

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