Fast turnover rates are associated with active histone modifications. (A) Heat map illustrating the relation between turnover rates and histone marks. Turnover indices were sorted from low to high (top to bottom). Relative enrichment (red = low, green = high) levels of various histone marks is shown. (B) Enrichment values for various histone marks were grouped into four bins with increasing enrichment levels and mean turnover indices were calculated for each bin. (C) Missing any of the five ‘active’ modifications decreases the H3.3 turnover index of enhancer nucleosomes. The turnover indices for enhancer H3.3 nucleosomes containing all five active modifications or missing one single modification are indicated on the y-axis. (D) Association with any of the five active modifications increases the turnover index of H3.3-nucleosomes at enhancers. The turnover indices for enhancer H3.3 nucleosomes containing none of the five active modifications or only one modification are indicated on the y-axis. (E) Association with either H3K27me3 or H3K36me3 decreases the turnover index of H3.3 nucleosomes. The turnover indices are indicated on the y-axis for H3.3 nucleosomes containing all five active modifications (only active) or five active modifications plus either H3K27me3 or H3K36me3 or both.