Figure 2
From: Temporal dynamics and transcriptional control using single-cell gene expression analysis
Temporal dynamics of THP-1 differentiation. (A) The multi-dimensional scaling (MDS) analysis reveals heterogeneous but population shifts in a time-dependent manner throughout the differentiation. (B) The centroids of each time point reveal temporal dynamics of cell populations throughout the time course, shifting from native, early-response, transition, to completion. (C) The coefficient of dispersion (COD) of three principal components (PC) and their variations shows distinct expression variation patterns throughout the time course and the associated TFs (blue TFs = positive contribution, red TFs = negative contribution).