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Table 2 In vivo assay of 12 liver enhancer predictions in mouse

From: Sequence signatures extracted from proximal promoters can be used to predict distal enhancers

ID

Coordinates [hg18]

Score

Location

Activity

Chromatin statea

E1

Chr16:30009197-30009301

3.07

Intronic ( TBX6 )

Yes

No

E7

Chr10:82023332-82023434

2.60

Intergenic (3' UTR of MAT1A)

No

Yes

E2

Chr17:69962796-69962894

2.21

Intergenic (4.5 kb downstream of GPRC5C)

No

No

E8

Chr1:31679030-31679149

1.94

Intronic ( SERINC2 )

Yes

Yes

E12

Chr3:134934911-134935091

1.81

Intronic (TF)

Yes

Yes

E4

Chr11:72138832-72139119

1.83

Intronic (ARAP1)

Yes

No

E5

Chr17:69957921-69958023

1.30

Intergenic (3′ UTR of GPRC5C )

Yes

No

E10

Chr17:69951076-69951329

1.57

Intronic ( GPRC5C )

Yes

Yes

E3

Chr11:72162942-72163179

1.47

Intronic (STARD10)

No

No

E9

Chr11:72168912-72169046

1.33

Intronic (STARD10)

No

Yes

E11

Chr11:72166225-72166509

1.36

Intronic ( STARD10 )

Yes

Yes

E6

Chr17:17439720-17439913

1.04

Intergenic (4 kb upstream of PEMT)

No

No

  1. aOverlaps with 'strong enhancer' Chromatin State Segmentation by HMM from Broad Institute, MIT, and MGH in HepG2 cell lines. Enhancer predictions for which we observed in vivo activity in mouse liver are highlighted in bold.