Age acceleration in colorectal cancer, glioblastoma multiforme and acute myeloid leukemia. (A
F) Results for colorectal cancer. Mean age acceleration (y-axis) in colorectal cancer versus mutation status (denoted by a plus sign) in (A)
K-RAS. (D) Promoter hyper methylation of the mismatch repair gene MLH1 (denoted by a plus sign) is significantly (P = 5.7E-5) associated with age acceleration. (E) Mean age acceleration across different patient groups defined by combinations of BRAF, TP53, K-RAS, MLH1 status. The first bar reports the age acceleration in normal adjacent colorectal tissue from cancer patients but the sample size of 4 is rather low. (F) CpG island methylator phenotype is associated with age acceleration (P = 3.5E-5). (G
R) Results for various genomic abnormalities in glioblastoma multiforme. (J) A highly significant (P = 3.3E-7) relationship can be found between H3F3A mutations and age acceleration. Samples with a G34R mutation have the highest age acceleration. (S
W) Results for various genomic aberrations in acute myeloid leukemia. (X) Thyroid cancer age acceleration versus RAS family mutation status is inconclusive since mutation status was largely unknown. Error bars represent 1 standard error.