Table 1 Demographic, clinical and histological characteristics of the samples
Characteristics | Diseased | Healthy | P-value |
|---|---|---|---|
n | 12 | 14 | |
Age (years) mean ± SD | 68.0 ± 10.81 | 61.14 ± 11.2 | 0.11 |
Ethnicity | Â | Â | Â |
Asian, Pacific Islander | 0 | 1 | Â |
White, non-Hispanic | 4 | 2 | Â |
Black, non-Hispanic | 4 | 4 | Â |
Hispanic | 1 | 3 | Â |
Other and unknown | 3 | 4 | Â |
Height (cm) mean ± SD | 165 ± 8.69 | 166.5 ± 8.63 | 0.6 |
Weight (kg) mean ± SD | 78.0 ± 22.02 | 88.32 ±15.93 | 0.2 |
BMI (kg/m2) mean ± SD | 27.85 ± 6.41 | 31.25 ± 5.58 | 0.18 |
Diabetes | 6 | 5 | Â |
Hypertension | 11 | 12 | Â |
Proteinuria (dipstick) | 3.0 ± 1.83 | 0.36 ± 0.81 | 1.80E-04 |
Serum BUN (mg/dL) mean ± SD | 35.0 ± 14.7 | 17.71 ±5.85 | 4.60E-04 |
Serum creatinine (mg/dL) mean ± SD | 3.0 ± 1.61 | 1.08 ± 0.18 | 2.00E-03 |
eGFR (ml/minute/1.73 m2) mean ± SD | 29.0 ± 13.68 | 70.94 ± 8.35 | 1.06E-09 |
Histology | Â | Â | Â |
Glomerulosclerosis (%) | 31.0 ± 31.35 | 3.31 ±5.52 | 4.00E-03 |
Mesangial matrix expansion | 1 ± 0.91 | 0.17 ± 0.39 | 0.03 |
Tubular atrophy (%) | 34.0 ± 24.94 | 9.82 ± 15.76 | 6.00E-03 |
Interstitial fibrosis (%) | 34.0 ± 25.15 | 5.68 ± 5.07 | 4.00E-04 |
Vascular sclerosis | Â | Â | Â |
Intima | 2.0 ± 0.78 | 0.9 ± 1.1 | 1.50E-03 |
Arterioles | 2.0 ± 0.78 | 0.29 ± 0.62 | 4.00E-04 |