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Table 1 Mutations that reduce growth control by pHc

From: Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pHc in Saccharomyces cerevisiae

Category Gene ORF Absolute pHca GO process
Inositol polyphosphates PLC1 YPL268W 6.92 (0.035) Inositol phosphate biosynthetic process
  KCS1 YDR017C 6.76 (0.047) Inositol phosphate biosynthetic process
Signal transduction LCB5 YLR260W 6.99 (0.034) Calcium-mediated signaling
  RHO5 YNL180C 7.02 (0.025) Rho protein signal transduction
Lipid synthesis CAX4 YGR036C 6.93 (0.057) Lipid biosynthetic process
  PDX3 YBR035C 6.99 (0.025) Fatty acid metabolic process
Vesicular transport RGP1 YDR137W 6.92 (0.031) Retrograde transport, endosome to Golgi
  CLC1 YGR167W 7.01 (0.049) Endocytosis
Mitochondria RSM24 YDR175C 7.01 (0.024) Mitochondrial translation
  MRPL27 YBR282W 7.00 (0.019) Mitochondrial translation
  MRPL16 YBL038W 6.97 (0.028) Mitochondrial translation
  MRPL37 YBR268W 6.98 (0.032) Mitochondrial translation
  MRPS5 YBR251W 7.00 (0.027) Mitochondrial translation
Various MSS2 YDL107W 7.00 (0.035) Protein insertion
  ILV1 YER086W 6.98 (0.035) Isoleucine biosynthetic process
  REF2 YDR195W 6.97 (0.072) mRNA processing
  CYC8 YBR112C 7.00 (0.032) Chromatin remodeling
Unknown AIM44 YPL158C 6.97 (0.024) Biological process unknown
  1. aWild-type pH average is 7.08 ± 0.05. Mutants were clustered according to pHc with respect to growth rate (Materials and methods) and grouped according to functionally related gene ontology (GO) processes.