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Table 1 Comparison of overlaps achieved by Braun et al. and our method when some of the initial Y2H interaction pairs are re-tested using LUMIER assay

From: A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Yeast strains implementation Number validated (LUMIER) Y2H PPIs Percentage overlap
Y strain 2 m 1 reporter 1 mM_3-AT (Braun et al.) 19 33 57
Y strain 2 m 2 reporters 1 mM_3-AT (Braun et al.) 13 22 59
Y strain CEN 1 reporter 1 mM_3-AT (Braun et al.) 17 23 74
MaV CEN 2 reporters 20 mM_3-AT (Braun et al.) 9 14 64
Our prediction 14 19 74
Our predictiona 10 11 91
  1. aThese pairs have LUMIER assay z-scores > 1.5.