Skip to main content
Figure 5 | Genome Biology

Figure 5

From: A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Figure 5

Functional insights from predicted interface. (a) Predicted interface for the interaction between BRAF (light blue) and PAK2 (red surface). Cancer-associated mutations that are annotated are shown in magenta. In dark blue we indicate mutations that are predicted to be associated with cancer but with no current annotations. The rest of the template structure is shown in gray. Mutations were taken from MoKCa database [78]. (b) Predicted interface for the interaction between MAPK6 (yellow) and YWHAZ (cyan). Phosphorylation sites on the proteins are indicated in red (S189 for MAPK6 and S184 for YWHAZ). The template used for the prediction was 1F5Q (chains A and B).

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us