Figure 2
From: Developmental features of DNA methylation during activation of the embryonic zebrafish genome
Characterization of promoter DNA methylation patterns during development through the MBT. (a) Average methylation profiles of HCPs and LCPs at pre-MBT, MBT and post-MBT stages. (b) Proportions of methylated HCPs and LCPs at pre-MBT, MBT and post-MBT stages; methylation is defined by detection of a methylation peak in the -1/0 kb window upstream of the TSS irrespective of downstream methylation (upstream (Up) and upstream/downstream (Up/Do) methylation; y-axis). a,bP = 0.0005; a,cP = 0.0027 (Fisher's test). (c) Percent increase in the numbers of genes methylated upstream of the TSS (Up-only; -1 to 0 kb), downstream of the TSS (Down-only; 0 to +1 kb), and both upstream and downstream (TSS), from pre-MBT to post-MBT. **P < 0.001 (Fisher) relative to increase in methylation in the whole regions analyzed (-5 to +1 kb).