TY - JOUR AU - Andersen, Ingrid S. AU - Reiner, Andrew H. AU - Aanes, Håvard AU - Aleström, Peter AU - Collas, Philippe PY - 2012 DA - 2012/07/25 TI - Developmental features of DNA methylation during activation of the embryonic zebrafish genome JO - Genome Biology SP - R65 VL - 13 IS - 7 AB - Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic demethylation and remethylation occurs after fertilization, during blastula stages, but how ZGA relates to promoter DNA methylation states is unknown. Using methylated DNA immunoprecipitation coupled to high-density microarray hybridization, we characterize genome-wide promoter DNA methylation dynamics before, during and after ZGA onset, in relation to changes in post-translational histone modifications and gene expression. SN - 1474-760X UR - https://doi.org/10.1186/gb-2012-13-7-r65 DO - 10.1186/gb-2012-13-7-r65 ID - Andersen2012 ER -