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Figure 6 | Genome Biology

Figure 6

From: m:Explorer: multinomial regression models reveal positive and negative regulators of longevity in yeast quiescence

Figure 6

Gene Ontology and pathway analysis of G 0 TFs.Quiescence genes with differential expression in G0 TF knockout microarrays were studied with ranked enrichment analysis in g:Profiler. Statistically significant non-redundant functional Gene Ontology categories are shown (hypergeometric test, FDR p ≤ 0.05). Black bars correspond to total number of G0 genes in a given category, and coloured bars show the number of times these genes were up-regulated (red) or down-regulated (green) in related G0 ΔTFs, according to knockout data. Enrichment p-value is shown in vertical colour strips on the left. Top: functional enrichments of quiescence genes associated to all G0TFs; middle: functional enrichments specific to TFs with reduced viability phenotype; bottom: Functional enrichments specific to WT+ TFs with increased viability phenotype. GO, Gene Ontology; TF, transcription factor.

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