Skip to main content

Table 1 Overview of SuMs in 13 complex diseases

From: Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

   

GWAS genes in PPI

GWAS genes in SuM

GWAS genes in core SuM

Disease

GEO accession

Genes in SuM

network

Observed

Expected

Observed

Expected

Asthma

GSE4302

587

8

1

0.39

0

0.04

Breast cancer

GSE10810

2,474

7

2

1.45

1

0.15

Chronic lymphocytic leukemia

GSE8835

1,787

11

3

1.64

0

0.17

Colorectal cancer

GSE9348

1,651

5

3

0.69

1

0.07

Crohn's disease

GSE6731

1,458

16

5

1.95

3

0.20

Lung adenocarcinoma

GSE7670

2,524

10

4

2.11

0

0.21

Obesity

GSE12050

2,268

13

4

2.47

0

0.25

Parkinson's disease

GSE20141

1,871

21

5

3.29

1

0.33

Prostate cancer

GSE6919

751

16

3

1.01

1

0.10

Psoriasis

GSE13355

2,274

12

8

2.28

1

0.23

Schizophrenia

GSE17612

1,586

18

4

2.39

0

0.24

Type 2 diabetes

GSE20966

1,658

21

5

2.91

2

0.29

Ulcerative colitis

GSE6731

2,365

25

13

4.95

3

0.50

Total

-

-

-

60

27.53

13

2.76

  1. Gene expression dataset for each disease obtained from the NCBI Gene Expression Omnibus (GEO).