Figure 3

Mutational bias between slow- and fast-dilution rate populations. (a) Frequency and pattern of different substitutional mutations. (b) Ratio between transition and transversion substitutions. (c) Mutation accumulation rates were estimated from the average number of observed mutations in slow growing populations, the number of generations, the effective population size and the mean selection coefficient per generation of all sequenced non-mutator isolates (24 from slow and 20 from fast dilution populations), as described in [52]. The error bars are the standard deviation based on replicate populations.