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Table 2 Function of the genes identified on the G2/M control

From: A systematic screen reveals new elements acting at the G2/M cell cycle control

Through CDK Tyr15 phosphorylation

Independent of

 
 

Upstream Sty1

Upstream Cdr1

Upstream Sty1, Cdr1

CDK Tyr15 phosphorylation

Not determined

wee1

pyp1

pom1

nif1

snf5

ppa2

clp1

gpa2

 

ski3

sol1

sgf73

 

pka1

  

zfs1

 
 

git3

    
 

git5

    
 

pab2

    
 

SPAC27E2.03c

    
 

SPBC19F8.02

    
  1. Analysis of the genetic interaction of the genes identified indicates that most of them act on the G2/M transition through CDK Tyr15 phosphorylation, directly on the CDK (Wee1), or indirectly, through Cdc25 (Clp1), the stress-nutritional response pathway (Pyp1, Gpa2, Pka1, Git3, Git5, Pab2, SPAC27E2.03c, SPBC19F8.02), the cell geometry sensing pathway (Pom1) or through both these two latter pathways (Nif1 and Ski3). The role of Snf5, Sol1 and Zfs1 in the G2/M control is independent of CDK Tyr15 phosphorylation, CDK inhibitor Rum1 and CDK protein levels. Genes in bold are those not previously associated with cell cycle control.