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Table 1 Splice events and PTC+ classification

From: Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

Tissue Splice event Total events PTC+ events Percentage PTC+ Exclusion events PTC upon exclusion Inclusion events PTC upon inclusion
BMM Total ES 730 281 38% 428 201 302 80
  Single ES 511    310 148 201 80
  Multiple ES 219    118 53 101 -
  A5SS 130 68 52%     
  A3SS 238 110 46%     
  MXE 44 5 11%     
  AFE 130 44 34%     
  ALE 49 NA NA     
Liver Total ES 3,102 1,285 41% 1,926 965 1,176 320
  Single ES 1,505    932 531 573 320
  Multiple ES 1,597    994 434 603 -
  A5SS 449 263 59%     
  A3SS 654 370 57%     
  MXE 475 66 14%     
  AFE 172 66 38%     
  ALE 143 NA NA     
  1. Splice isoform classes are shown for both single and multiple exon skipping (ES), alternative 5' splice site (A5SS), alternative 3' splice site (A3SS), mutually exclusive exons (MXE), alternative first exon (AFE) and alternative last exon (ALE). For ALE, no events were classified as PTC+, since the class relies on splicing to two different last exons. Here, a ΔPSI > 20% was required for all classes. NA, not applicable.