Figure 6

Relative performance of the top 11 immunity and defense host genes and virulence characteristics. Data were assessed by the ranking described in Figure 5 with respect to multivariate association between annotated genes and the virulence characteristics of the microbiome. The size of the nodes reflects the number of triples of genes whose first canonical correlation was at least 0.85 and whose second canonical correlation was at least 0.5. The thickness of the edges connecting the nodes reflects the number of triples whose first canonical correlation was at least 0.85 and whose second canonical correlation was at least 0.5. This plot summarizes the potential relationships between genes with respect to the virulence characteristics of the microbiome. ALOX5, arachidonate 5-lipoxygenase; AOC3, amine oxidase, copper containing 3 (vascular adhesion protein); BPIL1, bactericidal/permeability-increasing protein-like 1; DUOX2, dual oxidase 2; IL1A, interleukin 1 alpha; KLRF1, killer cell lectin-like receptor subfamily F, member 1; NDST1, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; REL, v-rel reticuloendotheliosis viral oncogene homolog; SP2, Sp2 transcription factor; TACR1, tachykinin receptor 1; VAV2, vav 2 guanine nucleotide exchange factor.