Propagation of expression changes into two-dose genes. (a,b) The probability of two-dose first-degree neighbors of one-dose genes changing expression by compensation response classification of the one-dose gene in females and males. (c,d) The proportions of two-dose first-degree genes with a positive direction of expression responses. Global averages for all two-dose genes are indicated (dotted lines). Significant differences from global values (P < 0.01, Chi-square test) are shown (asterisks). (e) Two-dose first-degree neighbors (elliptical nodes) of the anti-compensated gene atilla (rectangular node). Gene names are indicated for each node.