Figure 2

Mutations with intermediate effect (0.1 to 1 SD units) and low frequency (0.01 to 0.001) are not detected efficiently by either linkage or genome-wide association studies. Shown are the allele effect size (x-axis) and frequency (y-axis) for GWAS results from Lango Allen et al. [7] and for the sample of mutations described in Table 1. Assumptions for frequencies and effect of mutations from Table 1 are noted in the table footer.