Table 2 List of predefined interaction types

Acts on upstream signaling pathway

Competitive inhibition

Genetic

Indirect

Multimerization

Not specified

Physical: deacetylation

Physical: dephosphorylation

Physical: desumoylation

Physical: deubiqiutination

Physical: enzyme modification: acetylation

Physical: enzyme modification: methylation

Physical: enzyme modification: phosphorylation

Physical: enzyme modification: protein cleavage

Physical: enzyme modification: sumoylation

Physical: indirect altering posttranslational modifications

Physical: sequestering

Physical: translocation

Physical: ubiquitination

Physical: undefined direct interaction

Physical: with another TF

Physical: with another TF: complex binds DNA

Physical: with co-activator affecting recruitment

Physical: with co-repressor affecting recruitment

Regulatory: decreases expression of this TF

Regulatory: increases expression of this TF

Unknown