Figure 5

Comparison of c-Myc ChIP-Seq data between HeLaS3 and K562 cell lines. (a) Venn diagram showing the overlap of c-Myc binding site peaks between HeLaS3 and K562 cell lines. The overlap of cMyc peaks between the two cell lines was 65-fold greater than that observed for random permutations of the peak sets. (b,c) Hierarchical clustering of correlation coefficients of M value or -M value of all c-Myc peaks in HeLaS3 cells (b) and K562 cells (c) with the motif scores in the corresponding peak regions. Only significantly enriched motifs are shown. (d) Scatter plot of the M values determined for c-Myc binding versus the M values for H3K27ac based on ChIP-Seq comparisons between HeLaS3 and K562 cell lines.