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Figure 2 | Genome Biology

Figure 2

From: Population-specificity of human DNA methylation

Figure 2

Population specificity of DNA methylation heritability. (a) An example of a CpG site (near PLSCR2: chromosome 3, base 147696535) whose methylation is heritable in YRI, but not CEU, as assessed by the similarity of average parental methylation to their offspring methylation (each point represents one family trio). (b) Histograms comparing the observed distribution of per-site heritabilities to a typical randomized distribution (numbers in the text are based on 1, 000 randomizations; Materials and methods). The greater number of sites at high heritabilities in the real data compared to random (arrows) is an estimate of the number of heritable sites we can detect in each population. (c) No similarity between heritabilities in each population (Pearson's r 2 = 0.002; each point is a CpG site).

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