Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome coxidase

Table 1 Subcellular localization of human orthologs of yeast mitochondrial proteins

	Sequence	Profile	HMM	Total (localization)
Mitochondrial	338	37	42	417 (192^a)
Non-mitochondrial	63	10	19	92 (20^a)
Unknown	59	8	22	89
Total (method)	460	55	83	598

Subcellular localization of human orthologs of yeast mitochondrial proteins. In columns, we list numbers of proteins that contributed by sequence-to-sequence, sequence-to-profile and HMM-to-HMM method phases. Rows present known subcellular localization according to annotation based on the experimental evidence in human or mouse (Table S6 in Additional file 1). ^aCorroborated by data from both human and mouse independently.

ISSN: 1474-760X