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Figure 3 | Genome Biology

Figure 3

From: Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells

Figure 3

The PGC proteome. (a) A GeneMANIA-generated network seeded with the proteins specific to PGCs at 1-to-3 hours and linked to the most relevant 20 proteins predicted by GeneMANIA. (b) A GeneMANIA-generated network seeded with the proteins enriched in PGCs at 1-to-3 hours and linked to the most relevant 20 proteins predicted by GeneMANIA. The PGC-specific/enriched proteins are gray-filled circles. Proteins that function in germ plasm and/or PGC development are labeled in red. In each case the 20 most relevant predicted proteins are white-filled circles (if they were not detected by our MuDPIT analysis) or orange-filled (if they were detected by our MuDPIT analysis). The predictions of GeneMANIA were based on co-expression, co-localization, genetic interactions, physical interactions, predicted interactions, and shared protein domains [90]. All the detected proteins had a unique peptide number larger than two in the results from mass spectrometry.

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