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Table 1 Diverse functions of random monoallelic expression genes

From: Autosomal monoallelic expression in the mouse

Gene Class Full name Prominent molecular function(s) Most highly expressed in
Atxn1 RMAE I Ataxin 1 RNA binding Brain tissues, immune cells
Bcl2 RMAE I B-cell leukemia/lymphoma 2 Protease binding/transcription activator Blood progenitor cells
Inpp4a RMAE I Inositol polyphosphate-4-phosphatase, type I Phosphatase Testes
Myh10 RMAE I Myosin, heavy polypeptide 10, non-muscle Motor activity Many
Neb RMAE I Nebulin Actin binding Skeletal muscle
Rasgrp1 RMAE I RAS guanyl releasing protein 1 Nucleotide exchange factor, ion binding Brain tissues, immune cells
Slamf6 RMAE I SLAM family member 6 Receptor activity Immune cells
Zdhhc2 RMAE I Zinc finger, DHHC domain containing 2 Ion binding, transferase activity Bone marrow, brain tissues
Atp2a2 RMAE II ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Calcium binding/ATPase activity Heart
Bmpr1a RMAE II Bone morphogenetic protein receptor, type 1A Many Many
Cad RMAE II Carbonyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Enzymatic activity Embryonic stem cells
Creb1 RMAE II cAMP responsive element binding protein 1 DNA binding/transcription factor binding Many
Cul1 RMAE II Cullin 1 Ubiquitination Many
Dock9 RMAE II Dedicator of cytokinesis 9 Guanyl-nucleotide exchange Many
Esr1 RMAE II Estrogen receptor 1 (alpha) Binding factor Uterus, ovary, pituitary
Gart RMAE II Phosphoribosylglycinamide formyltransferase Nuclease binding/transferase activity Stem cell, blood progenitor cells
Igf2bp3 RMAE II Insulin-like growth factor 2 mRNA binding protein 3 Nucleotide binding/mRNA binding Embryo, placenta, osteoblasts
Kif1c RMAE II Kinesin family member 1C Nucleotide binding/microtubule motor Many
Lrp11 RMAE II Low density lipoprotein receptor-related protein 11 Receptor activity Pituitary, neuronal
Lyplal1 RMAE II Lysophospholipase-like 1 Hydrolase activity Adipose
Mapk8 RMAE II Mitogen-activated protein kinase 8 Nucleotide binding/kinase activity Many
Mtap2 RMAE II Microtubule-associated protein 2 Microtubule/neuronal structure Brain tissues
Myb RMAE II Myeloblastosis oncogene DNA binding/transcription regulation Blood progenitor
  1. Listed for a subset of RMAE genes is the gene name, the primary tissue(s) of expression and the gene function(s).