Table 1 Diverse functions of random monoallelic expression genes
Gene | Class | Full name | Prominent molecular function(s) | Most highly expressed in |
|---|---|---|---|---|
Atxn1 | RMAE I | Ataxin 1 | RNA binding | Brain tissues, immune cells |
Bcl2 | RMAE I | B-cell leukemia/lymphoma 2 | Protease binding/transcription activator | Blood progenitor cells |
Inpp4a | RMAE I | Inositol polyphosphate-4-phosphatase, type I | Phosphatase | Testes |
Myh10 | RMAE I | Myosin, heavy polypeptide 10, non-muscle | Motor activity | Many |
Neb | RMAE I | Nebulin | Actin binding | Skeletal muscle |
Rasgrp1 | RMAE I | RAS guanyl releasing protein 1 | Nucleotide exchange factor, ion binding | Brain tissues, immune cells |
Slamf6 | RMAE I | SLAM family member 6 | Receptor activity | Immune cells |
Zdhhc2 | RMAE I | Zinc finger, DHHC domain containing 2 | Ion binding, transferase activity | Bone marrow, brain tissues |
Atp2a2 | RMAE II | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Calcium binding/ATPase activity | Heart |
Bmpr1a | RMAE II | Bone morphogenetic protein receptor, type 1A | Many | Many |
Cad | RMAE II | Carbonyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Enzymatic activity | Embryonic stem cells |
Creb1 | RMAE II | cAMP responsive element binding protein 1 | DNA binding/transcription factor binding | Many |
Cul1 | RMAE II | Cullin 1 | Ubiquitination | Many |
Dock9 | RMAE II | Dedicator of cytokinesis 9 | Guanyl-nucleotide exchange | Many |
Esr1 | RMAE II | Estrogen receptor 1 (alpha) | Binding factor | Uterus, ovary, pituitary |
Gart | RMAE II | Phosphoribosylglycinamide formyltransferase | Nuclease binding/transferase activity | Stem cell, blood progenitor cells |
Igf2bp3 | RMAE II | Insulin-like growth factor 2 mRNA binding protein 3 | Nucleotide binding/mRNA binding | Embryo, placenta, osteoblasts |
Kif1c | RMAE II | Kinesin family member 1C | Nucleotide binding/microtubule motor | Many |
Lrp11 | RMAE II | Low density lipoprotein receptor-related protein 11 | Receptor activity | Pituitary, neuronal |
Lyplal1 | RMAE II | Lysophospholipase-like 1 | Hydrolase activity | Adipose |
Mapk8 | RMAE II | Mitogen-activated protein kinase 8 | Nucleotide binding/kinase activity | Many |
Mtap2 | RMAE II | Microtubule-associated protein 2 | Microtubule/neuronal structure | Brain tissues |
Myb | RMAE II | Myeloblastosis oncogene | DNA binding/transcription regulation | Blood progenitor |