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Table 2 The predicted rare drivers

From: DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

Dataset Gene Gband SNV/Indel HLAMP HOMD Corrected Pvalue Percent altered
METABRIC PTEN 10q23.31 0 0 16 0 1.54
METABRIC RB1 13q14.2 0 0 16 0 1.54
METABRIC MDM2 12q15 0 11 0 0 1.06
METABRIC MYC 8q24.21 0 10 0 0 0.96
METABRIC CDKN2A 9p21.3 0 0 16 0 1.54
METABRIC CLTC 17q23.1 0 16 0 0 1.54
METABRIC CREBBP 16p13.3 0 1 2 0 0.29
METABRIC GNAS 20q13.32 0 7 0 0 0.67
METABRIC EGFR 7p11.2 0 3 1 0 0.39
METABRIC CDH1 16q22.1 0 0 16 0 1.54
METABRIC CCNE1 19q12 0 6 1 0 0.67
METABRIC EP300 22q13.2 0 0 4 0 0.39
METABRIC CBL 11q23.3 0 0 13 0 1.25
METABRIC PIK3R1 5q13.1 0 0 2 1.00E-04 0.19
METABRIC JAK2 9p24.1 0 0 7 1.00E-04 0.67
METABRIC TP53 17p13.1 0 0 7 2.00E-04 0.67
METABRIC NUP98 11p15.4 0 0 8 0.0011 0.77
METABRIC ATM 11q22.3 0 0 15 0.0149 1.45
METABRIC PIK3CA 3q26.32 0 2 0 0.017 0.19
METABRIC IDH2 15q26.1 0 4 1 0.017 0.48
METABRIC KRAS 12p12.1 0 3 1 0.0348 0.39
METABRIC TRA@ 14q11.2 0 1 5 0.0388 0.58
TN JAK1 1p31.3 1 0 0 0.0026 1.5
HGS AKT2 19q13.2 0 3 1 0 1.32
HGS KIT 4q12 5 0 1 2.00E-04 1.97
HGS NRAS 1p13.2 2 0 0 9.00E-04 0.66
HGS RPN1 3q21.3 2 0 0 0.0019 0.66
HGS PIK3CA 3q26.32 2 0 0 0.0029 0.66
HGS CREBBP 16p13.3 5 0 1 0.0031 1.97
HGS PPP2R1A 19q13.33 3 0 1 0.0046 1.32
HGS ATIC 2q35 2 0 1 0.005 0.99
HGS CLTCL1 22q11.21 4 0 1 0.0068 1.64
HGS MET 7q31.2 4 0 0 0.0132 1.32
HGS MAP2K4 17p12 1 0 2 0.044 0.99
HGS ETV1 7p21.2 1 1 1 0.0468 0.99
HGS EP300 22q13.2 1 0 3 0.0492 1.32
GBM KRAS 12p12.1 1 0 1 1.41 1.67
GBM AKT1 14q32.33 0 1 0 1.64 0.83