Figure 1

Copy number of two gastric cancer genomes, mechanism of 12p amplification and creation of a fusion gene. (a) Somatic CNVs in the two gastric tumors (chromosomes are arranged on the x-axis, copy number is shown on the y-axis). (b) Copy number of chromosome 12 (top) and the amplicon on 12p (middle) are shown in orange (y-axis). Rearrangements identified by DNA-PET clusters with a size ≥ 45 are represented by arrows and connecting lines (bottom). Dark red and pink arrows represent 5' and 3' cluster regions, respectively, with the connection between the tip of the dark red and the blunt end of the pink arrows. Numbers represent cluster sizes. (c) Fusion between SOX5 and OVCH1 predicted by a rearrangement point with cluster size of 129 in (b).