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Table 1 Groups I to IV core chemical structures and reported activities

From: A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtiigrowth, motility and photosynthesis

Core structure group Phenotype PubChem bioassays (AID) Named drugs and uses
I Fitness PubChem AID 317390, 317391, 317396, 317399, 317400, 5512, 52703; displaces binding of sigma receptor, binds sigma receptor, binds 5HT-2A receptor, inhibits chemokine receptor 3 (CCR3)  
II Motility/Phototaxis PubChem AID31792; acetocholinesterase inhibitor Cyclizine, antihistamine; benethamine,
IIIa Photosynthesis PubChem AID1865, 2314, 2315, 2546, 504333, 493056; epigenetic regulator, shiga toxin inhibitor, inhibits retinoic acid related orphan receptor gamma, inhibits BAZ2B, increases thyrotropin releasing hormone receptor Darglitazone, muraglitazar, peroxisome proliferation activated receptor gamma, antiglycemic; oxaprozin, NSAID
IIIb Photosynthesis PubChem AID894, 1529, 145655, 5512; binds 5HT-2A receptor, inhibits MEK5 kinase, inhibits 15-hydroxyprostaglandin dehydrogenase Tolperisone, muscle relaxant
IV Active in all phenotypes PubChem AID265123, 265124, 265125, 265126, 265127; binds dopamine receptors D2, D3, D4, D1A Fezolamine, antidepressant; lonazole, NSAID, COX2 inhibitor