Table 1 Groups I to IV core chemical structures and reported activities
Core structure group | Phenotype | PubChem bioassays (AID) | Named drugs and uses |
|---|---|---|---|
I | Fitness | PubChem AID 317390, 317391, 317396, 317399, 317400, 5512, 52703; displaces binding of sigma receptor, binds sigma receptor, binds 5HT-2A receptor, inhibits chemokine receptor 3 (CCR3) | Â |
II | Motility/Phototaxis | PubChem AID31792; acetocholinesterase inhibitor | Cyclizine, antihistamine; benethamine, |
IIIa | Photosynthesis | PubChem AID1865, 2314, 2315, 2546, 504333, 493056; epigenetic regulator, shiga toxin inhibitor, inhibits retinoic acid related orphan receptor gamma, inhibits BAZ2B, increases thyrotropin releasing hormone receptor | Darglitazone, muraglitazar, peroxisome proliferation activated receptor gamma, antiglycemic; oxaprozin, NSAID |
IIIb | Photosynthesis | PubChem AID894, 1529, 145655, 5512; binds 5HT-2A receptor, inhibits MEK5 kinase, inhibits 15-hydroxyprostaglandin dehydrogenase | Tolperisone, muscle relaxant |
IV | Active in all phenotypes | PubChem AID265123, 265124, 265125, 265126, 265127; binds dopamine receptors D2, D3, D4, D1A | Fezolamine, antidepressant; lonazole, NSAID, COX2 inhibitor |