Figure 4

miR-185 mediates conserved crosstalk between Pbcas4 and BCAS4 and protein-coding gene ceRNAs in mouse and human. (a-c) An increased concentration of miR-185 in mouse and human neuroblastoma cells (N2A and SH-SY5Y cells, respectively) (a) leads to significant down-regulation of Pbcas4, BCAS4 and five mouse (b) and human (c) orthologous pairs that were predicted to compete for binding of miR-185. Asterisks indicate significance the level of the comparison (t-test) between the expression of target transcripts after transfection of negative control (set to 1) and miR-185 mimic (**P < 0.01; ***P < 0.001, NC; P > 0.01).