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Table 1 Description of DNA methylation data sets

From: Aging effects on DNA methylation modules in human brain and blood tissue

Set Analysis n Tissue Description Mean age Age range Platform Reference Public availability
1 Consensus 92 WB Dutch controls from ALS study 64 34-88 Infin 27 k Novel data GSE41037
2 Consensus 273 WB Dutch controls from SZ study 33 16-65 Infin 27 k Novel data GSE41037
3 Consensus 293 WB Dutch cases, SZ 34 17-86 Infin 27 k Novel data GSE41037
4 Consensus 190 WB Type 1 diabetics 44 24-74 Infin 27 k [15] GSE20067
5 Consensus 87 WB Healthy older women 63 49-74 Infin 27 k [14] GSE20236
6 Consensus 261 WB Healthy postmenopausal women from UKOPS 65 52-78 Infin 27 k [15, 33] GSE19711
7 Consensus 132 FCTX FCTX brain 48 16-101 Infin 27 k [18] GSE15745
8 Consensus 126 TCTX TCTX brain 48 15-101 Infin 27 k [18] GSE15745
9 Consensus 123 PONS PONS brain 46 15-101 Infin 27 k [18] GSE15745
10 Consensus 111 CRBLM CRBLM brain 47 16-96 Infin 27 k [18] GSE15745
11 Validation 94 WB 450 k Controls and SZ 32 18-65 Illumina 450 k Novel data GSE41169
12 Validation 24 MSCs MSCs 50 21-85 Infin 27 k [34, 35] GSE26519+GSE17448
13 Validation 50 CD14+CD4+ CD4+ T-cells and CD14+ monocytes 36 16-69 Infin 27 k [14] GSE20242
14 Validation 398 Leukocyte Pediatric population 10 3-17 Infin 27 k [24] GSE27097
15 Validation 72 Leukocyte Healthy children 5 1-16 Illumina 450 k [24] GSE36064
16 Validation 108 Prefrontal cortex Healthy controls 26 -0.5-84 Infin 27 k [19] BrainCloudMethyl
  1. Data sets 1 to 10 were used in the consensus network analysis while data sets 11 to 16 were used in the module validation (preservation) analysis. Our novel WB DNA methylation data sets (numbered 1 to 3 and 11) are composed of (n = 92 + 273 + 293 + 94) individuals. The study involved multiple tissues (blood, brain) and different populations (adults and healthy children). Note that the mean age (and age ranges) differ greatly across the studies. ALS, amyotrophic lateral sclerosis; CRBLM, cerebellum; FCTX, frontal cortex; MSC, mesenchymal stromal cell; PONS, caudal pons; SZ, schizophrenia; TCTX, temporal cortex; UKOPS, United Kingdom Ovarian Cancer Population Study; WB, whole blood.