Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Table 3 mRNA expression level of several markers associates with neuroblastoma risk factors, prognostic groups and survival

Grouping variable	Statistics	CNR1	GRB10	KRT19	PRPH	QPCT
Stage	Kruskal-Wallis P-value	<0.001	0.008	0.118	0.010	<0.001
MYCN	Mann-Whitney P-value	<0.001	<0.001	<0.001	<0.001	<0.001
Age cutoff 12 months	Mann-Whitney P-value	<0.001	0.609	<0.001	0.005	<0.001
Age cutoff 18 months	Mann-Whitney P-value	<0.001	0.810	<0.001	0.003	0.006
Overall survival status	Mann-Whitney P-value	<0.001	0.003	0.023	<0.001	<0.001
Prognostic group	Kruskal-Wallis P-value	<0.001	0.002	0.005	<0.001	<0.001

The statistical test used is shown and P-values (corrected for multiple testing using Benjamini-Hochberg) are indicated. P-values in bold indicate significant associations.