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Table 2 Several individual DNA methylation markers are associated with survival

From: Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Statistics KRT19 FAS CNR1 HIST1H3C ACSS3 GNAS
HR-DOD versus LR-SURV (P-value OS) 0.037 0.028 0.043 0.002 0.002 0.012
HR-DOD versus LR-SURV (P-value EFS) 0.039 0.049 0.039 0.039 0.079 0.039
HR-DOD versus LR-SURV and HR-SURV (P-value OS) 0.687 0.639 0.423 0.039 0.691 0.221
HR-DOD versus LR-SURV and HR-SURV (P-value EFS) 0.665 0.467 0.414 0.041 0.939 0.041
HR-DOD versus LR-SURV and HR-SURV (P-value OS (stratum))    Age < 12 months 0.035 Stage 4 0.033   MYCN = 0 0.033
HR-DOD versus LR-SURV and HR-SURV (P-value EFS (stratum))   Age < 12 months 0.014     MYCN = 0 0.001
  1. Log-rank test statistics (Mantel-Cox) are given (multiple testing correction by Benjamini-Hochberg) for comparison between the ultra-high risk group (HR-DOD) versus the low risk group (LR-SURV), and between the ultra-high risk group (HR-DOD) and all survivors (LR-SURV and HR-SURV). If a significant association (P < 0.05) was found in a particular stratum (associated with risk factors), this stratum is shown (multiple testing correction for the different comparisons by Benjamini-Hochberg). MYCN = 0: MYCN single copy ; EFS, event-free survival; OS, overall survival. P-values in bold indicate significant associations.