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Table 1 Several individual markers are differentially methylated between the prognostic groups and neuroblastoma risk factors

From: Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Type Subtype KRT19 FAS PRPH CNR1 QPCT HIST1H3C ACSS3 GRB10
Prognostic group LR-SURV 0/31 (0%) 1/31 (3%) 14/31 (45%) 2/31 (6%) 18/31 (58%) 0/31 (0%) 0/31 (0%) 6/31 (19%)
  HR-SURV 14/30 (48%) 8/30 (27%) 24/30 (80%) 10/30 (33%) 25/30 (83%) 2/30 (7%) 14/30 (47%) 13/30 (43%)
  HR-DOD 9/28 (32%) 6/28 (21%) 19/28 (68%) 10/28 (36%) 24/28 (86%) 6/28 (21%) 7/28 (25%) 11/28 (39%)
Stage Stage 1 0/21 (0%) 0/21 (0%) 8/21 (38%) 1/21 (5%) 13/21 (62%) 0/21 (0%) 0/21 (0%) 4/21 (19%)
  Stage 2 1/12 (8%) 2/12 (17%) 8/12 (67%) 2/12 (17%) 8/12 (67%) 0/12 (0%) 1/12 (8%) 3/12 (25%)
  Stage 3 9/17 (53%) 4/17 (24%) 13/17 (77%) 9/17 (53%) 15/17 (88%) 3/17 (18%) 9/17 (58%) 8/17 (47%)
  Stage 4 13/39 (33%) 9/39 (15%) 28/39 (72%) 10/39 (26%) 31/39 (80%) 5/39 (18%) 11/39 (28%) 15/39 (39%)
MYCN MYCN single copy 7/50 (14%) 2/50 (4%) 24/50 (48%) 5/50 (10%) 31/50 (62%) 0/50 (0%) 2/50 (4%) 14/50 (28%)
  MYCN amplified 16/39 (41%) 13/39 (33%) 33/39 (85%) 17/39 (44%) 36/39 (92%) 8/39 (21%) 19/39 (49%) 16/39 (41%)
Age Age at diagnosis > 12 months 21/53 (40%) 14/53 (26%) 37/53 (69%) 18/53 (34%) 46/53 (87%) 8/53 (15%) 21/53 (40%) 24/53 (45%)
  Age at diagnosis < 12 months 2/36 (6%) 1/36 (3%) 20/396(56%) 4/36 (11%) 21/36 (58%) 0/36 (0%) 0/36 (0%) 6/36 (17%)
  Age at diagnosis > 18 months 20/45 (44%) 13/45 (29%) 33/45 (73%) 17/45 (38%) 40/45 (89%) 8/45 (18%) 19/45 (49%) 23/45 (51%)
  Age at diagnosis < 18 months 3/44 (7%) 2/44 (5%) 24/44 (55%) 5/44 (11%) 27/44 (61%) 0/44 (0%) 2/44 (5%) 7/44 (16%)
Overall total   23/89 (26%) 15/89 (17%) 57/89 (64%) 22/89 (25%) 67/89 (75%) 8/89 (9%) 21/89 (24%) 30/89 (34%)
Statistics (Fisher's exact P-value)          
Prognostic group   <0.001 0.151 0.112 0.068 0.165 0.0624 <0.001 0.405
MYCN   0.0594 0.008 0.008 0.008 0.017 0.0146 <0.001 0.708
Stage   0.007 0.287 0.221 0.059 0.683 0.448 0.008 0.700
Age cutoff 12 months   0.008 0.045 0.579 0.138 0.059 0.123 <0.001 0.059
Age cutoff 18 months   0.002 0.045 0.326 0.059 0.045 0.0594 0.0015 0.012
  1. The number (percentage) of methylated samples in each stratum is given. P-values according to the Fisher's exact test, corrected for multiple testing (Benjamini-Hochberg). HR-DOD, high-risk deceased patients; HR-SURV, high-risk patients alive for at least 1,000 days follow-up; LR-SURV, low-risk patients alive for at least 1,000 days follow-up. P-values in bold indicate significant associations.