Epigenetic transgenerational inheritance of somatic transcriptomes and epigenetic control regions

Table 1 Pathway enrichment for 11 male and female rat tissue signature lists

	11 male and female tissues	Sex and tissue
		Male							Female
		6 tissues	Heart	Kidney	Liver	Prostate	SV	Testis	5 tissues	Heart	Kidney	Liver	Ovary	Uterus
Pathway name
Number of genes in input list	4059	3046	172	725	266	1112	274	552	1298	408	151	99	305	279
Total number of affected pathways	230	224	79	151	141	191	90	99	191	108	79	29	80	138
Pathways in cancer	45	32	3	7	6	13	1	2	17	6	3	1	3	4
Protein processing in endoplasmic reticulum	39	38	3	4	1	22	5	4	3	1			1	1
HTLV-I infection	39	31		8	3	14	3	2	10	4	2		1	3
RNA transport	39	31	1	8		17	3	6	11	4		1	2	4
Transcriptional misregulation in cancers	31	26	1	8	6	7	4	3	12	6	3	1		3
Herpes simplex infection	30	23	2	10	3	7	2	1	9	3	1		2	3
Lysosome	29	27	1	5	4	16	2	2	5	1			1	3
Ribosome	29	27	2	5		1		20	4	1	1	2
Endocytosis	29	26	1	4	8	11	1	3	5	2				3
Phagosome	28	27	1	6	6	12		2	7		3			4
MAPK signaling pathway	28	21	1	7	3	7	1	2	8	3			1	4
Spliceosome	27	17		8	1	1	2	7	12	6	1		1	5
Regulation of actin cytoskeleton	26	24	1	6	6	9		3	5	3		1		1
Alzheimer's disease	26	22	2	4		7		10	5				2	3
Huntington's disease	26	22	1	6		2		14	5	1		1	2	1
Purine metabolism	26	22	1	6	2	4	2	6	7	2				5
Focal adhesion	26	21	2	2	7	8		3	9	3		2		4
Chemokine signaling pathway	24	23	3	4	6	9	1	1	4				2	2
Pyrimidine metabolism	24	20	1	6	1	6	1	5	6	1		1	1	3
Tuberculosis	24	20		6	6	9	1		9	1	1			7
Influenza A	23	21	1	5	2	11	1	3	5	1	2			2
Oxidative phosphorylation	23	20	1	4		5		11	5		1		1	3
Leukocyte transendothelial migration	22	18	2	1	7	8		1	6	4	1			1
Cytokine-cytokine receptor interaction	21	19	1	6	7	6			4	3				1
Osteoclast differentiation	21	18	1	2	6	10	1		5	1			1	3
Cell adhesion molecules	20	14	2	3	4	6	1		7	3	1		1	2
Insulin signaling pathway	19	13		2	3	6	2		6	2				4
mRNA surveillance pathway	19	13	1	4		5	2	4	8	4			2	2

HTLV, human T-lymphotropic virus; MAPK, mitogen-activated protein kinase; SV, seminalvesicle.

ISSN: 1474-760X