Estimated fold enrichment of eQTNs in putative regions of active chromatin. The plots show the enrichment of eQTNs within DNaseI hypersensitive peaks, or within regions marked by a number of histone modifications. (a) All locations within the cis region around each gene. Error bars show 95% confidence intervals. Arrows indicate that the confidence interval extends beyond the left end of the x-axis. (b) Open chromatin 5 to 100 kb upstream of the gene TSS. (c) Estimated probability that a random SNP is an eQTN as a function of distance from the TSS (grey bars) or the conditional probability of a random SNP being an eQTN, given that it lies outside or inside a DNaseI hypersensitive site, or within a DNaseI site overlapped by two or more histone marks.