TY - JOUR AU - Scheinfeldt, Laura B. AU - Soi, Sameer AU - Thompson, Simon AU - Ranciaro, Alessia AU - Woldemeskel, Dawit AU - Beggs, William AU - Lambert, Charla AU - Jarvis, Joseph P. AU - Abate, Dawit AU - Belay, Gurja AU - Tishkoff, Sarah A. PY - 2012 DA - 2012/01/20 TI - Genetic adaptation to high altitude in the Ethiopian highlands JO - Genome Biology SP - R1 VL - 13 IS - 1 AB - Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, including EPAS1, EGLN1, and PPARA, which play a role in the HIF-1 pathway. Here, we have extended this work to high- and low-altitude populations living in Ethiopia, for which we have measured hemoglobin levels. We genotyped the Illumina 1M SNP array and employed several genome-wide scans for selection and targeted association with hemoglobin levels to identify genes that play a role in adaptation to high altitude. SN - 1474-760X UR - https://doi.org/10.1186/gb-2012-13-1-r1 DO - 10.1186/gb-2012-13-1-r1 ID - Scheinfeldt2012 ER -