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Figure 7 | Genome Biology

Figure 7

From: First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum

Figure 7

Accumulation of mutant E2F1 protein in cells due to increased stability of E2F1-R166H. (a) E2F1 protein levels detected by anti-E2F1 antibody (KH95) 48 hours after transfection. WT, wild type. (b) Degradation assay performed in MSTO-211H cells over-expressing E2F1 treated with 25 μg/ml cycloheximide. Levels of E2F1 protein were monitored every 30 minutes for 3 hours using anti-E2F1 antibody.

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Genome Biology

ISSN: 1474-760X

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