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Table 4 Mean allele balances of heterozygous SNVs genome-wide and in CTRs

From: Comparison of solution-based exome capture methods for next generation sequencing

   Control I Additional samples  
Exome capture method Number of samples Genome-widea CTRb Genome-widea CTRb Student's t-test Pc
Agilent SureSelect 3 0.517 0.524 0.511 0.517 0.007
Agilent SureSelect 50 Mb 3 0.515 0.520 0.514 0.519 0.003
NimbleGen SeqCap 20 0.516 0.527 0.514 0.523 7.1 × 10-15
NimbleGen SeqCap v2.0 3 0.512 0.518 0.514 0.519 0.013
  1. aAll called heterozygous SNVs with minimum sequencing coverage of 20×, regardless of target region. bHeterozygous SNVs with minimum sequencing coverage of 20× called within the CTRs. cStudent's t-test P-value for the difference between CTR and all sequenced regions given for the combined sample set of the control I sample and 25 additional samples.