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Figure 3 | Genome Biology

Figure 3

From: Exome sequencing identifies a missense mutation in Isl1associated with low penetrance otitis media in dearisch mice

Figure 3

Histology of the middle ear. (a) A normal unaffected translucent bulla in an unaffected animal. (b) An abnormally white bulla with a small engorged capillary (indicated by the arrowhead) from an affected animal. (c) An unaffected animal with a normal transparent tympanic membrane and the malleus (M) and incus (Inc) visible beneath. (d) The tympanic membrane is opaque with engorged capillaries on the surface (indicated by arrowheads). This animal also showed raised ABR thresholds. (e) A normal malleus from an unaffected animal. (f) A malleus (M) with fused incus (Inc) and extraneous bony growth on the malleus head and manubrium (Man) from an affected animal. This represents the most extreme example of extraneous bony growth. (g) Crystalline deposits found in the middle ear cavity of an affected animal. Scale bars: 1 mm (a, b); 0.5 mm (c-f); 0.2 mm (g).

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