Skip to main content

Table 3 Allele frequency among unrelated deaf and controls of the same population of origin as the proband

From: Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families

    Allele frequency in population of origin (number of chromosomes)
Gene Mutation Origin of proband Unrelated deaf (sample size) Controls (sample size)
TMC1 p.R604X Morocco, Jewish 0.058 (6/104) 0 (0/256)
TMC1 p.S647P Morocco, Jewish 0.337 (35/104) 0.028 (16/564)
CDH23 p.V2635F Algeria, Jewish 0.192 (5/26) 0 (0/106)
MYO15A p.R2728H Ashkenazi Jewish 0.010 (3/288) 0 (0/316)
MYO15A p.R125VfsX101 Ashkenazi Jewish 0.008 (1/120) 0.006 (3/480)
MYO15A p.E1414K Palestinian Arab 0.005 (2/434) 0 (0/480)
WFS1 p.E864K Ashkenazi Jewish 0 (0/102) 0 (0/100)
TECTA p.T1866M Turkey, Jewish 0.067 (1/15) 0 (0/270)