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Table 6 Efficacy of variant elimination due to linkage peak filtering

From: Reducing the exome search space for Mendelian diseases using genetic linkage analysis of exome genotypes

Family

Model

Consanguinity

Number of linkage peaks

Max LOD

Number of not synonymous exonic variants

Number of (%) not synonymous exonic variants in linkage regions

A

Recessive

First cousin offspring

15

1.2

10,982

604 (5.50)

T

Recessive

First cousins once removed offspring

5

1.51

11,353

65 (0.57)

M

Dominant

None

41

0.3

13,186

2,478 (18.79)