Figure 2

Coverage distribution. (a) Coverage across exon targets. Per-sample read depth of the 8,000 targets in all CEU and TSI samples. Targets were ordered by median per-sample read coverage (black). For each target, the upper and lower decile coverage value is also shown. Upper panel: samples sequenced with Illumina. Lower panel: samples sequenced with 454. (b) Cumulative distribution of base coverage at every target position in every sample. Depth of coverage is shown for all Exon Pilot capture targets, ordered according to decreasing coverage. Blue, samples sequenced by Illumina only; red, 454 only; green, all samples regardless of sequencing platform.